Hotels in Florida Keys

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Apr 18 - Apr 19
Tomorrow
Apr 19 - Apr 20
This weekend
Apr 18 - Apr 20
Next weekend
Apr 25 - Apr 27

Where to stay in Florida Keys?

Santa Maria Suites
Courtyard

Santa Maria Suites

4.0 star property
9.6 out of 10, Exceptional, (1002)
The price is $595
includes taxes & fees
$529 per night
May 11 - May 12
Santa Maria Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Florida Keys

Showing deals for:May 2 - May 4

Image gallery for Isla Bella Beach Resort & Spa

Property grounds
VIP Access

Isla Bella Beach Resort & Spa

5.0 star property
Marathon
9.0/10Wonderful (1,010 reviews)
30% off
Price is $405
per night
$1,043 total
includes taxes & fees
Isla Bella Beach Resort & Spa

Top neighborhoods in Florida Keys

Key West Historic District

Old Town Key West

Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.

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Old Town Key West

Top landmarks in Florida Keys

Duval Street featuring signage

Duval Street

If you want to give your credit card some exercise, head out to Duval Street, a popular place for shoppers in Key West Historic District. Splash some more cash at We Cycle Key West and Mallory Dock.

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Duval Street

Learn more about Florida Keys

Florida Keys is admired for its seaside and live music while top attractions include Everglades National Park and Duval Street. This beachside city has something for everyone including its entertainment, bars, and sights like Vaca Key and Florida Keys Country Club.

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Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people

Frequently asked questions

What hotels do travelers like in Florida Keys?
Almond Tree Inn Hotel - Adults Only, Kona Kai Resort and Gallery and The Mermaid & Alligator are all properties that our guests really like.
Can I book a refundable hotel in Florida Keys?
If you need the flexibility to change your plans to Florida Keys, most properties provide refundable* rates you can book. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Florida Keys hotels do our guests like for their terrific location?
Our guests rave about the location of these properties: Faro Blanco Resort & Yacht Club, Reefhouse Resort & Marina and Isla Bella Beach Resort & Spa. For a quiet locale, travelers like Waterside Suites & Marina.
Where can I stay in Florida Keys if I want a budget-friendly accommodation?
Two inexpensive options worth considering are Chesapeake Beach Resort and The Pelican Key Largo Cottages. You can browse more choices on our site, including 12 motels.
Where can I stay in Florida Keys if I want a vacation home instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, browse our selection of 4186 vacation homes. In addition, there are 391 apartments and 1237 condos.
Why should I book my Florida Keys hotel through Hotels.com?
There are lots of reasons to book your Florida Keys trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.