Hotels in Southeast Minnesota

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
Apr 23 - Apr 24
Tomorrow
Apr 24 - Apr 25
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

Where to stay in Southeast Minnesota?

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Exterior

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 star property
8.8 out of 10, Excellent, (738)
The price is $135
includes taxes & fees
$117 per night
May 16 - May 17
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top neighborhoods in Southeast Minnesota

Rochester showing skyline and a city

Downtown Rochester

Rochester's Downtown Rochester neighborhood has a host of places to visit such as Mayo Civic Center and Rochester Civic Theater.

See properties in Downtown Rochester
Downtown Rochester

Top landmarks in Southeast Minnesota

Winona State University

Winona State University

Enjoy the collegiate vibe when you visit Winona State University, during your trip to Winona. Stroll along the riverfront or experience the area's museums.

See properties in Winona State University
Winona State University

Learn more about Southeast Minnesota

Southeast Minnesota is well-known for its sports and riverfront, featuring attractions such as Mayowood Mansion and Cascade Lake Beach. Visitors to this family-friendly city speak highly of the restaurants whereas sights include Apache Mall and Plummer House.

See all hotels in Southeast Minnesota
Rochester showing skyline and a city
Photo by Howard Lower Photography
Open Photo by Howard Lower Photography
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

What accommodations do travelers recommend in Southeast Minnesota?
Round Barn Farm B & B Event Center, Hilton Rochester Mayo Clinic Area and Alexander Mansion Bed and Breakfast are all accommodations that are popular with guests.
Can I book a refundable hotel in Southeast Minnesota?
If you need the flexibility to change your travel plans to Southeast Minnesota, most properties offer refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Which Southeast Minnesota hotels do guests like for their great location?
Travelers like these properties for their convenient location: Kahler Inn and Suites - Mayo Clinic Area, Kahler Grand Hotel and La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S. For a quiet locale, travelers like Best Western Rochester Hotel Mayo Clinic Area/St. Mary’s.
Where can I stay in Southeast Minnesota if I want an affordable accommodation?
A few inexpensive options worth considering are Hampton Inn Rochester-South, Best Western Rochester Hotel Mayo Clinic Area/St. Mary’s and Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic. You can browse more choices on our site, including 15 motels.
Where can I stay in Southeast Minnesota if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, browse our selection of 359 vacation homes. In addition, there are 96 apartments and 47 condos.
Why should I book my Southeast Minnesota accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Minnesota travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

https://www.hotels.com/lp/b/deals