Hotels in Southern Indiana

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Where to stay in Southern Indiana?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southern Indiana

Showing deals for:May 2 - May 4

Top neighborhoods in Southern Indiana

Top landmarks in Southern Indiana

Learn more about Southern Indiana

Southern Indiana is applauded for its live music and entertainment with such cultural attractions as French Lick Scenic Railway and Santa Claus Museum. The city has something for everyone including its casinos, restaurants, and sights like Patoka Lake Swimming Beach and Patoka Lake.

Kentucky Center for the Performing Arts featuring modern architecture
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*

Frequently asked questions

What accommodations do travelers like in Southern Indiana?
The Destination B&B, Hilton Garden Inn Jeffersonville and The Pepin Mansion Historic B&B are all properties that our guests really like.
Can I book a refundable hotel in Southern Indiana?
If you want the flexibility to change your travel plans to Southern Indiana, most hotels provide refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Southern Indiana hotels do travelers like for their great location?
Our guests rave about the location of these properties: Galt House Hotel Trademark Collection by Wyndham, Omni Louisville Hotel and Holiday Inn Express & Suites Louisville Downtown, an IHG Hotel.
Where should I consider staying in Southern Indiana if I want a cheap accommodation?
Two inexpensive options worth considering are Holiday Inn Express & Suites Louisville Downtown, an IHG Hotel and Baymont by Wyndham Evansville East. You can browse more choices on our site, including 23 motels.
Where can I stay in Southern Indiana if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, review our selection of 328 vacation homes. In addition, there are 185 apartments and 47 condos.
Why should I book my Southern Indiana hotel with Hotels.com?
There are plenty of reasons to book your Southern Indiana travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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