Hotels in Northeast Missouri

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Apr 23 - Apr 24
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Apr 24 - Apr 25
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Apr 25 - Apr 27
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May 2 - May 4

Where to stay in Northeast Missouri?

The Knight Center at Washington University
Reception

The Knight Center at Washington University

2.5 star property
9.4 out of 10, Exceptional, (284)
The price is $165
includes taxes & fees
$144 per night
May 23 - May 24
The Knight Center at Washington University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Northeast Missouri, MO

Showing deals for:May 2 - May 4

Image gallery for Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Lounge

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4.0 star property
St. Louis
8.8/10Excellent (1,001 reviews)
Member Price available
Price is $198
per night
$471 total
includes taxes & fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Top neighborhoods in Northeast Missouri

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Clayton

St. Louis's Clayton neighborhood is known for its restaurants and museums, and entices visitors with attractions including Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center.

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Clayton

Top landmarks in Northeast Missouri

Busch Stadium

Busch Stadium

Why not catch an event at Busch Stadium, a major stadium in Downtown St. Louis. Our travelers also like the art galleries and museums in the area. If you think Busch Stadium is cool, you also might like Enterprise Center and Dome at America’s Center, both located nearby.

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Busch Stadium

Learn more about Northeast Missouri

Northeast Missouri is well-known for its baseball and live music while top attractions include Enterprise Center, St. Louis Zoo, and St. Louis Union Station. This family-friendly city has something for everyone including its theaters, restaurants, and sights like Busch Stadium and Mark Twain Birthplace State Historic Site.

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St. Louis which includes interior views
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What accommodations do travelers recommend in Northeast Missouri?
The Green Tree Inn, River Sirens Hotel and Central Hotel are all properties that our guests really like.
Can I book a refundable accommodation in Northeast Missouri?
If you want the flexibility to change your travel plans to Northeast Missouri, most properties provide refundable* bookable rates. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Northeast Missouri hotels do our guests like for their central location?
Travelers like these properties for their convenient location: Live by Loews - St.Louis, Moonrise Hotel and OYO Hotel St. Louis Downtown City Center MO.
Where should I stay in Northeast Missouri if I want a cheap accommodation?
Pear Tree Inn St. Louis Airport, Quality Inn & Suites Hannibal and Sleep Inn & Suites O’Fallon MO - Technology Drive are a few accommodations you might want to consider that’ll save you money. You may want to browse more choices on our site, including 43 motels.
Where can I stay in Northeast Missouri if I want a vacation home instead of a traditional hotel?
If you want to find a good alternative to a hotel, review our selection of 829 vacation homes. In addition, there are 846 apartments and 159 condos.
Why should I book my Northeast Missouri hotel through Hotels.com?
There are plenty of reasons to book your Northeast Missouri travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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