Hotels in Southeast Missouri

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Where to stay in Southeast Missouri?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Top landmarks in Southeast Missouri

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.

Frequently asked questions

What accommodations do travelers recommend in Southeast Missouri?
Echo Bluff State Park, Hampton Inn Cape Girardeau I 55 East and Hampton Inn Poplar Bluff are all properties that our guests really like.
Can I book a refundable accommodation in Southeast Missouri?
If you need the flexibility to change your travel plans to Southeast Missouri, most hotels provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Southeast Missouri hotels do our guests like for their great location?
Travelers like these properties for their convenient location: Auburn Place Hotel And Suites, Pear Tree Inn Cape Girardeau Near the Medical Center and Courtyard by Marriott Cape Girardeau Downtown.
Where can I stay in Southeast Missouri if I want a cheap accommodation?
Auburn Place Hotel And Suites, Pear Tree Inn Cape Girardeau Near the Medical Center and Candlewood Suites Cape Girardeau, an IHG Hotel are a few accommodations you might want to consider that’ll save you money. You may want to browse more choices on our site, including 21 motels.
Where can I stay in Southeast Missouri if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, look over our selection of 129 vacation homes. In addition, there are 46 apartments and 7 condos.
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Southeast Missouri

Find out more about Southeast Missouri

Whispers of the River: Unveiling the Blossoms and Spirit of Southeast Missouri

Discover the charm of Southeast Missouri, where nature and culture intertwine along the banks of the majestic Mississippi River. Explore the scenic trails of the Ozark foothills, bursting with vibrant wildflowers in spring. Visit the lively town of Cape Girardeau, home to Southeast Missouri State University, where art, history, and community thrive. Enjoy riverfront parks, unique local shops, and rich cultural experiences. Whether you're hiking the picturesque landscapes or savoring local cuisine, Southeast Missouri offers a refreshing escape for adventurers and romantics alike, making it a hidden gem in the heart of the Midwest. For great hotel rates near Southeast Missouri, be sure to check out Hotels.com's Last-Minute DealsOpens in a new window on travel.

Discover great hotels near Southeast Missouri

Southeast Missouri offers a range of hotel accommodations, from budget-friendly options to comfortable mid-range properties. You'll find welcoming stays near Southeast Missouri State University and local hospitals, making it convenient for both leisure and business travelers. Enjoy a variety of amenities that cater to your needs. Here are some of our travelers' favorite hotels near Southeast Missouri:

  1. Madison Inn LodgeOpens in a new window: Madison Inn Lodge is a welcoming 2.5-star motel that offers a comfortable and cozy atmosphere for leisure travelers. This property features clean and well-maintained rooms, ensuring a pleasant stay. With a focus on providing a friendly environment, travelers appreciate the helpful staff and the peaceful ambiance. The hotel also includes a breakfast bar, enhancing the overall guest experience. Pet-friendly amenities allow for a more inclusive experience for those traveling with pets, making it an excellent choice for those seeking a relaxed getaway in Southeast Missouri.
  2. Shepherd Mountain InnOpens in a new window: Shepherd Mountain Inn is a charming 2.5-star hotel that caters to leisure travelers looking for a cozy retreat. This property shines with its inviting rooms and thoughtful amenities, including a delightful breakfast that offers a variety of options, perfect for fueling up before a day of exploration. The motel’s close proximity to outdoor activities, such as mountain biking, makes it an ideal base for adventure seekers. The warm and accommodating service enhances the experience, ensuring visitors feel well taken care of during their stay.

5 tips for savvy savings when booking a hotel near Southeast Missouri

  1. Book for the cheapest times: The most budget-friendly time to visit Southeast Missouri is during January, November, and December, when hotel prices tend to be lower. For those looking to immerse themselves in the area's rich history and culture, a stay of at least 2 to 3 days is recommended. This timeframe allows visitors to explore significant landmarks, picturesque rivers, and vibrant floral displays, all while enjoying great value for money. With the potential for prices to drop during these months, it’s an ideal time for travelers on a budget to discover the beauty and heritage of Southeast Missouri.
  2. Look for last-minute deals on Hotels.com: To uncover last-minute deals to Southeast Missouri, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window sections on Hotels.com, where you may discover discounted hotel rates as your travel date approaches. Consider enabling email alerts or push notifications to stay updated on flash sales and last-minute promotions, helping you save on your stay. Additionally, utilize Smart ShoppingOpens in a new window through the app, a comparison tool that allows you to compare hotel prices and amenities, so you can be the first to know if rooms become available or prices drop for your ideal getaway.
  3. Be flexible with dates: Prices can fluctuate based on factors like the hotel's location, star rating, and the time of year. Being flexible with your travel dates might help you save on your stay near a Southeast Missouri hotel. For those seeking unique accommodations, boutique hotels often provide a more personalized experience and may offer better value. When you book through Hotels.com, we’ll inform you if the price for your chosen dates is above or below the average. If the price seems high, we’ll suggest alternative dates that could be more affordable, increasing your chances of finding a better deal.
  4. Consider your location: Staying near major attractions or city centers can be convenient, but it typically comes with higher prices. For more budget-friendly options, consider hotels in less central neighborhoods, where you can find a better balance between cost and accessibility to the sights you want to see. You might also look into independent hotels located a bit further out, as they often provide a more authentic experience at a more affordable rate.
  5. Join One Key™: Become a One Key MemberOpens in a new window for free and book your next stay near Southeast Missouri. Save on over 100,000 hotels worldwide with exclusive member prices. As a member, you can quickly progress through the tiers and enjoy perks, like free room upgrades when available and food and beverage discounts at select VIP Access properties.

Best time to go to Southeast Missouri

Southeast Missouri experiences its lowest average temperature in January, at 34.9°F (1.6°C), while July is the hottest month, with an average temperature of 79.2°F (26.2°C). April tends to be the wettest month.