Business Hotels in Clayton

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
Aug 5 - Aug 6
Tomorrow
Aug 6 - Aug 7
This weekend
Aug 8 - Aug 10
Next weekend
Aug 15 - Aug 17

Business Hotels in Clayton

Hyatt Regency St. Louis at The Arch
Relax in the elegant lobby, featuring a comfortable seating area with a sofa and armchairs, a staircase, and a chandelier.

Hyatt Regency St. Louis at The Arch

4.0 star property
8.4 out of 10, Very Good, (3911)
$101 nightly
The price is $119
Aug 22 - Aug 23
Total includes taxes and fees
Hyatt Regency St. Louis at The Arch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top neighborhoods in Clayton

Meeting of the Waters Fountain showing a statue or sculpture and a fountain
Downtown St. Louis map

Downtown St. Louis

St. Louis's Downtown St. Louis neighborhood is known for its concert halls and museums, and entices visitors with attractions including Gateway Arch and Busch Stadium.

Central West End
Central West End map

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Creve Coeur map

Creve Coeur

St. Louis's Creve Coeur neighborhood is known for its restaurants and offers a host of things to see such as Creve Coeur Golf Club and Saint Louis Abbey.

St. Louis which includes interior views
Downtown West map

Downtown West

St. Louis's Downtown West neighborhood has a host of places to visit such as St. Louis Union Station and St. Louis Aquarium at Union Station.

Soulard
Soulard map

Soulard

St. Louis's Soulard neighborhood has a host of places to visit such as Anheuser-Busch Brewery and Soulard Farmer's Market.

Top landmarks in Clayton

Busch Stadium
Busch Stadium

Busch Stadium

Why not catch an event at Busch Stadium, a major stadium in Downtown St. Louis. Our travelers also like the art galleries and museums in the area. If you think Busch Stadium is cool, you also might like Enterprise Center and Dome at America’s Center, both located nearby.

See properties in Busch Stadium
St. Louis Union Station
St. Louis Union Station

St. Louis Union Station

If you're planning a bit of sightseeing head to St. Louis Union Station— just one of the monuments in Downtown West. Why not live the cultural experience and visit the art galleries and museums in the area— your sightseeing tour starts here.

See properties in St. Louis Union Station

Frequently asked questions

What are the best business hotels in Clayton?
One of the top business hotels in Clayton according to guests is The Lodge At Grant's Trail. Take advantage of a conference space and daily housekeeping services here. Four Seasons Hotel St Louis is another popular option with frequent business travelers.
What are the cheapest business hotels in Clayton?
Hampton Inn & Suites St. Louis at Forest Park is a budget-friendly option catering to professionals. This property features a 24-hour front desk and a 24-hour business center. Also check out Hampton Inn St. Louis-Downtown (At the Gateway Arch). Search for affordable Clayton business hotels that are a win for both your wallet and your work.
What is the best time to stay in a business hotel in Clayton?
If you're after the warmest weather, organize your work trip for July. The temperatures are around 70ºF (21ºC) to 88ºF (31ºC) then. January sees the coolest temperatures between 25ºF (-4ºC) and 37ºF (3ºC). For a more relaxed vibe and potentially cheaper business hotels in Clayton, visit in January when it's quieter.
What are the closest business hotels to Chapel of St. Timothy And St. Titus, Concordia Seminary?
Seal those deals at your business hotel in Clayton and then head out to explore Chapel of St. Timothy And St. Titus, Concordia Seminary. The Knight Center at Washington University is near this attraction and comes with a cafe and buffet breakfasts. Or, hit those deadlines and then hit the top sights from Moonrise Hotel. It's another stay that's only a short drive away.
What business hotels in Clayton have a pool?
Four Seasons Hotel St Louis is a popular Clayton business hotel with a pool. Plus, you'll have access to a cafe and an electric car charging station during your visit. For more options where you can enjoy a swim after a busy day, look up Drury Plaza Hotel St. Louis at the Arch.
What are the closest business hotels to Lambert-St. Louis Intl. Airport (STL)?
Get off the plane and then get straight into your next meeting at Drury Inn & Suites St. Louis Airport. This business stay is about 1 mile southeast of Lambert-St. Louis Intl. Airport (STL). You can make use of a swimming pool, free long-distance calls and more here. Wingate by Wyndham St. Louis Airport is another great choice. Explore the full range of business hotels in Clayton or nearby that were made for traveling professionals.
What are the best 5-star business hotels in Clayton?
With a cafe and a swimming pool, Four Seasons Hotel St Louis caters to executives who demand the best. Another 5-star Clayton business hotel that promises to upgrade your work trip is The Ritz-Carlton, St. Louis.
Are there any business hotels in Clayton with parking?
Make business trips smoother by staying at The Lodge at Grant's Trail. This getaway comes with parking, a conference space and a free breakfast. Four Seasons Hotel St Louis is another stay that includes a spot to leave your ride. If you want to see what else is available, check out the 1,783 Clayton business hotels with parking.
Are all taxes and fees included in the Clayton hotel prices shown on Hotels.com?
Hotels.com provide upfront pricing so you can relax knowing you won't be met with surprise additional fees or taxes when you're ready to confirm your booking. From the time you start your search on Hotels.com, the price you see is what you pay. This makes it much easier to compare properties and secure our best deal for your next getaway.