Hotels in Potosi

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Tonight
Apr 25 - Apr 26
Tomorrow
Apr 26 - Apr 27
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

Where to stay in Potosi?

Comfort Inn & Suites Regional Medical Center
Front of property - evening/night

Comfort Inn & Suites Regional Medical Center

2.5 star property
8.4 out of 10, Very Good, (874)
The price is $95
includes taxes & fees
$82 per night
May 18 - May 19
Comfort Inn & Suites Regional Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Potosi

While on a recent family roadtrip I stumbled across this amazing stained glass on the campus. I was driving to a different area to go shooting and felt obligated to stop and shoot this amazing work! I love exploring unfamiliar areas to find these photographic gems!

Hardin Simmons University

If you'd like to get a taste of Abilene student life, check out Hardin Simmons University, located 1.9 mi (3 km) from central Abilene.

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Hardin Simmons University

Learn more about Potosi

The region around Potosi is home to attractions such as Taylor County Expo Center and Mall of Abilene.

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A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers recommend in Potosi?
Guests like MCM Elegante Suites Abilene, Doubletree by Hilton Abilene Downtown Convention Center and Courtyard by Marriott Abilene Southwest/Abilene Mall South.
Can I book a refundable accommodation in Potosi?
If you want the flexibility to change your plans to Potosi, most hotels provide refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay in Potosi if I want a vacation home instead of a hotel?
If you’re looking for a good alternative to a hotel, review our selection of 6 vacation homes.
Where can I stay if I'm visiting Potosi for a family-friendly vacation?
Parents traveling with children may want to consider Country Cottage By the Pool.
What will the weather in Potosi be like during my trip?
The warmest months in Potosi are usually August and July with an average temp of 83°F. January and February are the chilliest months when the average temp is 50°F. The rainiest months are May and September.
Why should I book my Potosi accommodation with Hotels.com?
There are plenty of reasons to book your Potosi travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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